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Fisetin, a naturally occurring flavonoid found in fruits like strawberries and apples, has gained significant attention for its potential health benefits. Research suggests it may support healthy aging, cognitive function, and cellular health. Choosing the best fisetin supplement requires careful consideration. This guide reviews top contenders in 2022.
What is Fisetin & Why Supplement?
While obtainable through diet, achieving therapeutic doses of fisetin solely through food is challenging. Supplementation offers a concentrated and convenient way to potentially reap its benefits. Key areas of research include:
- Senolytic Activity: Fisetin shows promise in clearing senescent (“zombie”) cells, which contribute to age-related decline.
- Cognitive Support: Studies indicate potential for improved memory and neuroprotection.
- Anti-inflammatory Effects: Fisetin may help modulate inflammatory responses.
- Antioxidant Properties: It combats oxidative stress, protecting cells from damage.
Life Extension Fisetin
Key Features: Highly reputable brand, standardized extract, often third-party tested. Contains 100mg of fisetin per capsule. Good bioavailability due to formulation.
Pros: Trusted source, quality control.
Cons: Price point can be higher.
NOW Supplements Fisetin
Key Features: Affordable option, vegetarian/vegan friendly. Contains 100mg fisetin per capsule.
Pros: Cost-effective, widely available.
Cons: May lack the extensive third-party testing of premium brands.
Doctor’s Best Fisetin
Key Features: Bioavailability enhanced with BioPerine® (black pepper extract). 100mg fisetin per serving.
Pros: Improved absorption, reputable brand.
Cons: BioPerine may cause mild digestive upset in some individuals.
NutriGenesis Fisetin
Key Features: Focus on whole-food derived ingredients. Offers a unique formulation.
Pros: Natural sourcing.
Cons: Potency may vary slightly.
Factors to Consider When Choosing
- Dosage: Most studies use dosages between 100-500mg daily.
- Bioavailability: Look for formulations with bioavailability enhancers like piperine.
- Third-Party Testing: Ensures purity and potency. Look for certifications like USP or NSF.
- Brand Reputation: Choose established brands with a history of quality.
- Form: Capsules are the most common and convenient form.
Potential Side Effects & Precautions
Fisetin is generally considered safe, but some individuals may experience mild side effects like digestive upset. Consult with a healthcare professional before taking fisetin, especially if you have existing medical conditions or are taking medications. It may interact with certain drugs.
